Gilbert NM, O'Brien VP, Lewis AL. Transient Microbiota Exposures activate dormant Escherichia coli infection in the bladder and drive severe outcomes of recurrent disease. PLoS Pathog. 2017 Mar 30;13(3):e1006238. doi: 10.1371/journal.ppat.1006238. eCollection 2017 Mar. PMID:28358889

Robinson LS, Lewis WG, LewisAL. The Sialylate O-acetylesterase from Gut Bacteroidetes Species Enables Sialidase-mediated Cross-Species Foraging of 9-O-acetylated Sialoglycans. J. Biol. Chem. 2017 Jul 14;292(28): 11861-11872. doi: 10.1074/jbcM116.769232 PMID: 28526748.

Amegashie CP, Gilbert NM, Peipert JF, Allsworth JE, Lewis WG, Lewis AL. Relationship between Nugent Score and Vaginal Epithelial Exfoliation. PLoS One. 2017 May 31;12(5):e0177797. doi: 10.1371/journal.pone.0177797. PMID28562623


Kline, KA; Lewis, AL. Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract.  Microbiology Spectrum. 2016, March 11; 4(2)

Yamaguchi, M; Hirose, Y, Nakata, M; Uchiyama, S; Yamaguchi, Y; Goto, K; Sumitomo, T; Lewis, AL; Kawabata, S; Nizet, V. Evolutionary Inactivation of a Sialidase in group B Streptococcus. Sci Rep. 2016 Jun 29;6:28852. doi: 10.1038/srep28852. PMID 27352769

 Lewis, WG and Lewis, AL. A New Catalog of Microbiological Tools for Women's Infectious Disease Research. Genome Announc. 2016 Sep 29;4(5). pii: e00890-16. doi: 10.1128/genomeA.00890-16. PMID 2768833 

 O'Brien VP, Hannan TJ, Yu L, Livny J, Roberson ED, Schwartz DJ, Souza S, Mendelsohn CL, Colonna M, Lewis AL, Hultgren SJ. A mucosal imprint left by prior E. coli bladder infection sensitizes to recurrent disease. Nat Microbiol. 2016 Oct 31;2:16196. doi: 10.1038/nmicrobiol.2016.196. PMID: 27798558

 Lewis, AL; Robinson, LS; Agarwal, K; and Lewis, WG. Discovery and characterization of de novo sialic acid biosynthesis in the phylum Fusobacterium. Glycobiology. 2016 2016 Oct;26(10):1107-1119. doi: 10.1093/glycob/cww068. PMID: 27613803

Lewis, WG and Lewis, AL. A New Catalog of Microbiological Tools for Women's Infectious Disease Research. Genome Annouc. 2016 Sep 29;4(5). pii: e00890-16. doi: 10.1128/genomeA.00890-16. PMID 2768833 

Robinson, LR; Perry, JC; Lek, S; Wollam, A; Sodergren, E; Weinstock, G; Lewis, AL; Lewis, WG.  Draft genome sequences of 15 Gardnerella vaginalis strains isolated from the vaginas of women with and without bacterial vaginosis. Genome Announc. 2016 Sep 29;4(5). pii: e00879-16. doi: 10.1128/genomeA.00879-16. PMID 27688326

Lewis, AL; Deitzler, G; Ruiz, M; Weimer, C; Park, S; Robinson, L; Wollam, A; Hallsworth-Pepin, K; Mitreva, M; Lewis; WG. Draft genome sequences of 11 human vaginal isolates of Actinobacteria. Genome Announc. 2016 Sep 29;4(5). pii: e00887-16. doi: 10.1128/genomeA.00887-16. PMID 27688328

Deitzler, G; Ruiz, M; Weimer, C; Park, S; Robinson, L; Wollam, A; Hallsworth-Pepin, K; Mitreva, M; Lewis, AL; Lewis, WG. Draft genome sequences of 14 Firmicutes isolated from the human vagina. Genome Announc. 2016 Sep 29;4(5). pii: e00888-16. doi: 10.1128/genomeA.00888-16. PMID 27688329

Deitzler, G; Ruiz, M; Lu, W; Robinson, L; Weimer, C; Park, S; Wollam, A; Hallsworth-Pepin, K; Mitreva, M. Lewis, WG; Lewis, AL; Draft Sequences of Seven Gram-Negative Vaginal Bacteria. Genome Announc. 2016 Sep 29;4(5). pii: e00889-16. doi: 10.1128/genomeA.00889-16. PMID 2768833

Weimer, C; Deitzler, G; Ruiz, M; Robinson, L; Park, S; Hallsworth-Pepin, K; Mitreva, M; Lewis, W; Lewis, AL. Genome Sequences for 12 Bacterial Isolates Obtained from the Urine of Pregnant Women. Genome Announc. 2016 Sep 29;4(5). pii: e00882-16. doi: 10.1128/genomeA.00882-16. PMID 27688327


Kline, K.A.; Schwartz, D.J.; Gilbert, NM; Lewis, A.L. Impact of Host Age and Parity on Susceptibility to Severe Urinary Tract Infection in a Murine Model. PLoS One. 2014 May 16;9(5):e97798. PMID: 24835885

Lubin, J.B.; Lewis, W.G.; Gilbert, N.M.; Almagro-Moreno, S.; Boyd, E.F.; Lewis, A.L Host-like carbohydrates promote bloodstream survival of Vibrio vulnificus in vivo. Infect Immun. 2015 Aug;83(8):3126-36. Epub 2015 May 26.PMID: 2601547


 Lewis, WG; Robinson, LS; Gilbert, NM; Lewis, AL. Degradation, Foraging, and Depletion of Mucus Sialoglycans by the Vaginal-Adapted Actinobacterium Gardnerella vaginalis. J Biol Chem. 2013 Apr 26;288(17):12067-79. PMID: 23479734

Faculty of 1000 Recommended, Highlighted in Town and Style magazine and Fit Pregnancy Magazine              

 Gilbert, NM; Lewis, WG; Robinson, LS;  Lewis, AL. Clinical Features of Bacterial Vaginosis in a Murine Model of Vaginal Infection with Gardnerella vaginalis. PLoS One. 2013;8(3):e59539. doi: 10.1371/journal.pone.0059539. Epub 2013 Mar 19. PMID: 23527214

Highlighted in Town and Style magazine and Fit Pregnancy Magazine

Gilbert, NM; O’Brien, V; Hultgren, S; Macones, GA; Lewis, WG; Lewis, AL. Urinary Tract Infection as a Preventable Cause of Pregnancy Complications: Opportunities, Challenges, and a Global Call to Action.   Global Adv. Health Med. 2013;2(5):59-69. PMID: 24416696


Lewis, WG; Robinson, LS; Perry, JC; Bick, JL; Peipert, JF; Allsworth, JE; Lewis, AL. 2012. Hydrolysis of Secreted Immunoglobulin A (IgA) in ex Vivo and Biochemical Models of Bacterial Vaginosis. J Biol Chem. 287(3): 2079-89. PMID: 22134918

Highlighted in the ASBMB Blog “Wild-types”

Ricaldi,JN; Matthias, MA; Vinetz, JM; Lewis, AL. 2012 Expression of Sialic Acids and other Nonulosonic Acids in LeptospiraBMC Microbiol. 12 (1):161. PMID: 22853805

Kline, K.A.; Schwartz, D.J.; Gilbert, NM; Hultgren, S.J.; Lewis, A.L. Immune Modulation by Group B Streptococcus  Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic E. coli. Infect. Immun. 2012 Dec;80(12):4186-94. PMID 22988014

Lewis AL, Lewis WG. 2012. Host Sialoglycans and Bacterial Sialidases: A Mucosal Perspective. Cell Microbiol. 2012 14(8):1174-82. PMID: 22519819


Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. 2010. O-Acetylation of Sialic Acid on Group B Streptococcus Inhibits Neutrophil Suppression and Virulence. Biochem J.428(2):163-8.

Lewis, A.L.; Lubin, J.B.; Argade, S.; Naidu, N.; Choudhury, B.; and Boyd, E.F. 2011. Genomic and Metabolic Profiling of Nonulosonic Acids in Vibrionaceae reveal Biochemical Phenotypes of Allelic Divergence in V. vulnificus Appl. Environ. Microbiol. Aug;77(16):5782-93. PMID: 21724895

Kline, K.A.; Schwartz, D.J.; Lewis, W.G.; Hultgren, S.J.; Lewis, A.L. 2011. Immune Activation and Suppression by Group B Streptococcus in a Murine Model of Urinary Tract Infection. Infect Immun. Sep;79(9):3588-95. PMID: 21690238


Carlin, A.; Uchiyama, S.; Chang, Y.; Lewis, A.L.; Nizet, V.; Varki, A. 2009. Molecular Mimicry of Host Sialylated Glycans Allows a Bacterial Pathogen to Engage Neutrophil Siglec-9 and Dampen the Innate Immune Response. Blood. 113(14):3333-6.

Pannaraj PS, Edwards MS, Ewing KT, Lewis AL, Rench MA, Baker CJ. 2009. Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation. Vaccine.16;27 (33):4452-6.

Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. 2009. Genetic and Biochemical Modulation of Sialic Acid O-Acetylation on Group B Streptococcus: Phenotypic and Functional Impact. Glycobiology. (11):1204-13.

Lewis, A.L.; Varki, A. Evolutionary Considerations in Studying the Sialome: Sialic Acids and the Host-Pathogen Interface. Bioinformatics for Glycobiology and Glycomics: An Introduction.  pgs 69-88. Wiley & Sons Ltd. 2009.

Lewis, A.L.; Desa, N.; Hansen, E.E.; Knirel, Y.; Gordon, J.; Gagneux, P.; Nizet, V.; Varki, A. 2009. Innovations in Host and Microbial Sialic Acid Biosynthesis Revealed by Phylogenomic Prediction of Nonulosonic Acid Structure. Proc. Natl. Acad. Sci. U S A. 11;106 (32):13552-7.


Lewis, A.L.; Cao, H.; Patel, S.K.; Diaz, S.; Ryan, W.; Carlin, A.F.; Thon, V.; Lewis, W.G.; Varki, A.; Chen, X.; Nizet, V. 2007. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in Group B Streptococcus. J. Biol. Chem. 282 (38):27562-71.

Carlin, A.F.; Lewis, A.L.; Varki, A.; Nizet, V. 2007Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol. 189(4):1231-7.

Lewis, A.L.; Hensler, M.; Nizet, V; Varki, A. 2006. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem.  281(16):11186.

Lewis, A. L.; Altheide, T.K.; Varki, A.; Arden, K.; Varki, N.M. 2005Combining Parenting and a Science Career. Science 307(5716): 1720.

Hayakawa, T.; Angata,T.; Lewis, A.L.; Mikkelsen, T.; Varki, N.; Varki, A. 2005. A human-specific gene in microgliaScience 309 (5741):1693.

Lewis, A.L.; Nizet, V.; Varki. A.  2004. Discovery and Characterization of Sialic Acid O-Acetylation in Group B StreptococcusProc. Nat. Acad. Sci. U.S.A. 101(30): 11123-11128

Doolittle, R.F.; York, A.L. 2002Bacterial Actins? An Evolutionary Perspective. BioEssays 24: 293-296.